Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.

@article{Lorenzo2002IsomerspecificAO,
  title={Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.},
  author={Diego Di Lorenzo and Raffaella Villa and Giorgio Biasiotto and Sara Belloli and Giuseppina Ruggeri and Alberto Albertini and Pietro Apostoli and Michele Raviscioni and Paolo Ciana and Adriana C Maggi},
  journal={Endocrinology},
  year={2002},
  volume={143 12},
  pages={
          4544-51
        }
}
We investigated the tissue-specific effects of dichlorodyphenyltrichloroethane (DDT) isomers in adult and suckling newborn mice, using a novel mouse line engineered to express a reporter of estrogen receptor transcriptional activity (ERE-tkLUC mouse). The DDT isomers p,p'-DDT [1,1,1-trichloro2,2-bis(p-chlorophenyl) ethane] and o,p'-DDT [1,1,1-trichloro-2(p-chlorophenyl)-2-(o-chlorophenyl) ethane] were specifically selected as a weak and a strong estrogen, respectively. In adult male mice, p,p… CONTINUE READING

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