Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.

@article{Chang2011IsomalyngamideAA,
  title={Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.},
  author={Tzu Ting Chang and Shivaji V. More and I-Hsuan Lu and Jui-Ching Hsu and Ting-Ju Chen and Ya Ching Jen and Chung-Kuang Lu and Wen-Shan Li},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 9},
  pages={3810-9}
}
Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p… CONTINUE READING