Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase.


The purpose of this research was to study isomalt as a protein-stabilizing excipient with lactate dehydrogenase (LDH) during freeze-drying and subsequent storage and compare it to sucrose, a standard freeze-drying excipient. Four different diastereomer mixtures of isomalt were studied. The stability of the protein was studied with a spectrophotometric… (More)
DOI: 10.1016/j.ijpharm.2018.01.015


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