Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells.

@article{Kumar2007IsoliquiritigeninII,
  title={Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells.},
  author={Sarvesh Kumar and Amritansh Sharma and Babita Madan and Vandana Singhal and Balaram Ghosh},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 10},
  pages={1602-12}
}
Isoliquiritigenin (ILTG) is a flavonoid with chalcone structure (4,2',4'-trihydroxychalcone), an active component present in plants like Glycyrrhiza and Dalbergia which showed various biological activities including anti-inflammatory, anti-carcinogenic and antihistamic. As very little is known in regard to the underlying mechanism involved in explaining the various activities of the compound, we carried out a detailed study on the effect of ILTG on the expression of cell adhesion molecules on… CONTINUE READING