Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6.

@article{Zhao2014IsoliquiritigeninAF,
  title={Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6.},
  author={Haixia Zhao and Xinhua Zhang and Xuewei Chen and Ying Li and Zunqiong Ke and Tian Tang and Hongyan Chai and Austin Meng Guo and Honglei Chen and Jing Yang},
  journal={Toxicology and applied pharmacology},
  year={2014},
  volume={279 3},
  pages={311-21}
}
M2 macrophage polarization is implicated in colorectal cancer development. Isoliquiritigenin (ISL), a flavonoid from licorice, has been reported to prevent azoxymethane (AOM) induced colon carcinogenesis in animal models. Here, in a mouse model of colitis-associated tumorigenesis induced by AOM/dextran sodium sulfate (DSS), we investigated the chemopreventive effects of ISL and its mechanisms of action. Mice were treated with AOM/DSS and randomized to receive either vehicle or ISL (3, 15 and 75… CONTINUE READING

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