Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain

  title={Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain},
  author={Naotaka Horiguchi and Y. Ago and S. Hasebe and Kosuke Higashino and K. Asada and Yuki Kita and K. Takuma and T. Matsuda},
  journal={Pharmacology Biochemistry and Behavior},
Social isolation rearing in mice after weaning reduces pain sensitivity to acute pain, and this hypoalgesia is mediated by the descending serotonergic pain inhibitory system in which the spinal serotonin (5-HT)1A receptor is involved. However, it is not known whether isolation rearing affects pain sensitivity to neuropathic or inflammatory chronic pain. In this study, we examined the effects of isolation rearing on chronic pain induced by Freund's complete adjuvant (FCA) and partial sciatic… Expand
Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice.
Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice
Anxiolytic-like effects of restraint during the dark cycle in adolescent mice


Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats
Selective disturbance of pain sensitivity after social isolation
5-HT(1A) receptors in endogenous regulation of neuropathic hypersensitivity in the rat.
Involvement of Spinal Serotonin Receptors in Electroacupuncture Anti-Hyperalgesia in an Inflammatory Pain Rat Model
Interaction of Morphine and Selective Serotonin Receptor Inhibitors in Rats Experiencing Inflammatory Pain
Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation
Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain
High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury.
Peri-adolescence isolation rearing alters social behavior and nociception in rats