Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain

@article{Horiguchi2013IsolationRR,
  title={Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain},
  author={Naotaka Horiguchi and Y. Ago and S. Hasebe and Kosuke Higashino and K. Asada and Yuki Kita and K. Takuma and T. Matsuda},
  journal={Pharmacology Biochemistry and Behavior},
  year={2013},
  volume={113},
  pages={46-52}
}
Social isolation rearing in mice after weaning reduces pain sensitivity to acute pain, and this hypoalgesia is mediated by the descending serotonergic pain inhibitory system in which the spinal serotonin (5-HT)1A receptor is involved. However, it is not known whether isolation rearing affects pain sensitivity to neuropathic or inflammatory chronic pain. In this study, we examined the effects of isolation rearing on chronic pain induced by Freund's complete adjuvant (FCA) and partial sciatic… Expand
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