Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.

@article{Bortolato2011IsolationRR,
  title={Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.},
  author={Marco Bortolato and Paola Devoto and Paola Roncada and Roberto Frau and Giovanna Flore and Pierluigi Saba and Giuseppa Pistritto and Alessio Soggiu and Salvatore Pisanu and Agata Zappal{\`a} and Maria Serafina Ristaldi and Maria Tattoli and Vincenzo Cuomo and Francesco Marrosu and Maria Luisa Barbaccia},
  journal={Neuropharmacology},
  year={2011},
  volume={60 7-8},
  pages={1301-8}
}
Isolation rearing (IR), a well-established rat model of early chronic psychosocial stress, engenders marked behavioral alterations related to changes of dopamine (DA) neurotransmission in cortical and subcortical brain regions. Stress-induced shifts in γ-aminobutyric acid (GABA)-ergic signaling have been implicated in the dysregulation of DA release. The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone/AP), synthesized from progesterone by the action of the rate-limiting enzyme 5… CONTINUE READING

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