Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.

@article{Bottino2007IsolationOA,
  title={Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.},
  author={Rita Bottino and Appakalai N. Balamurugan and Cynthia Smetanka and Suzanne Bertera and Jing Jing He and Pleunie P. M. Rood and David K. C. Cooper and Massimo Trucco},
  journal={Xenotransplantation},
  year={2007},
  volume={14 1},
  pages={74-82}
}
INTRODUCTION Pig islets have been proposed as an alternative to human islets for clinical use, but their use is limited by rejection. The availability of genetically modified pigs devoid of alpha1,3-galactosyltransferase might provide islets more suitable for xenotransplantation. To limit the costs involved in the logistics and health care of pigs for clinical xenotransplantation, we have studied whether younger, rather than older, pigs that are typically preferred can be used as islet donors… CONTINUE READING

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