Isolation of tumor suppressor genes in melanoma by cDNA microarray.

  title={Isolation of tumor suppressor genes in melanoma by cDNA microarray.},
  author={Yan A. Su and Jeffrey M. Trent},
  journal={Methods in molecular medicine},
The multistep genetic alterations thought to involve both oncogenes and tumor suppressor genes that are causally related to melanocytic transformation remain largely undetermined (1). Mapping of alterations to chromosome 6 indicates that multiple genetic loci on 6q contribute causally to the development and progression of malignant melanoma (1). This notion is also supported by the introduction of chromosome 6 in malignant melanoma cell lines suppressing either their tumorigenicity (2) or… CONTINUE READING


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