Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.

@article{Staal1977IsolationOT,
  title={Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.},
  author={S P Staal and Janet W. Hartley and Wallace P. Rowe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 7},
  pages={3065-7}
}
Murine leukemia viruses capable of malignant transformation of mink tissue culture cells have been isolated from an AKR thymoma cell line and from a spontaneous reticulum cell sarcoma in an NIH Swiss mouse partially congenic for the AKR ecotropic virus-inducing locus Akv-2. In contrast to the recently described mink cell focus-inducing strains of murine leukemia virus, at least one of the two transforming strains is replication defective. Nonproducer mink cells carrying the genome of the… CONTINUE READING

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