Isolation of the thrombospondin membrane receptor.

  title={Isolation of the thrombospondin membrane receptor.},
  author={Adam S. Asch and John W. Barnwell and Roy L Silverstein and Ralph L. Nachman},
  journal={The Journal of clinical investigation},
  volume={79 4},
Thrombospondin (TSP), a 450-kD multifunctional glycoprotein with a broad tissue distribution, is secreted upon platelet stimulation, binds to the activated platelet surface, and supports platelet aggregation. We have identified and isolated an 88-kd membrane glycoprotein present in platelets, endothelial cells, monocytes, and a variety of human tumor cell lines that is the membrane binding site for TSP. Endogenous platelet TSP binding to thrombin- and ionophore-stimulated human platelets was… CONTINUE READING
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