Isolation of the dorsal locus of Drosophila

@article{Steward1984IsolationOT,
  title={Isolation of the dorsal locus of Drosophila},
  author={R. Steward and Francis J McNally and Paul Schedl},
  journal={Nature},
  year={1984},
  volume={311},
  pages={262-265}
}
The establishment of embryonic polarity is a crucial step in pattern formation and morphogenesis. In the fruitfly Drosophila melanogaster, embryonic polarity depends primarily on genes expressed in the female during oogenesis. Mutations in these ‘maternal effect’ genes can lead to major disruptions in normal pattern formation. Two classes of maternal genes essential for the establishment of polarity in the embryo have been identified. Lesions in one class, the ‘bicaudal’ genes, disrupt the… CONTINUE READING

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