Isolation of the causal virus of infectious salmon anaemia (ISA) in a long-term cell line from Atlantic salmon head kidney.

@article{Dannevig1995IsolationOT,
  title={Isolation of the causal virus of infectious salmon anaemia (ISA) in a long-term cell line from Atlantic salmon head kidney.},
  author={Birgit Helene Dannevig and Knut Falk and Ellen Namork},
  journal={The Journal of general virology},
  year={1995},
  volume={76 ( Pt 6)},
  pages={1353-9}
}
A long-term cell line (SHK-1) supporting replication of the causal virus of infectious salmon anaemia (ISA) has been established. The cell line was developed from a culture of Atlantic salmon (Salmo salar L.) head kidney cells. CPE was observed in SHK-1 cells 12-14 days after inoculation with ISA-infective tissue material. The time for CPE to develop decreased after repeated passages of medium from infected cell cultures to new cultures. Transmission trials demonstrated that Atlantic salmon… CONTINUE READING
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