Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: expression and physiological function

@article{Mio1997IsolationOT,
  title={Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: expression and physiological function},
  author={Toshiyuki Mio and Toshiko Yamada-Okabe and Tomio Yabe and Tasuku Nakajima and Mikio Arisawa and Hisafumi Yamada‐Okabe},
  journal={Journal of Bacteriology},
  year={1997},
  volume={179},
  pages={2363 - 2372}
}
Cell wall beta-glucan in a pathogenic fungus, Candida albicans, is highly branched with beta-1,3 and beta-1,6 linkages. We have isolated the C. albicans cDNAs for KRE6 and SKN1, the genes required for beta-1,6-glucan synthesis in Saccharomyces cerevisiae. The results of Northern blot analysis revealed that C. albicans KRE6 was expressed at a higher level than SKN1 in the yeast phase, while SKN1 expression was strongly induced upon induction of hyphal formation. In addition, the C. albicans KRE6… 

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