Isolation of temperature-sensitive CHO-K1 cell mutants exhibiting chromosomal instability and reduced DNA synthesis at nonpermissive temperature.

@article{Tsuji1990IsolationOT,
  title={Isolation of temperature-sensitive CHO-K1 cell mutants exhibiting chromosomal instability and reduced DNA synthesis at nonpermissive temperature.},
  author={Hideo Tsuji and Yuji Matsudo and Satsuki Tsuji and Fumio Hanaoka and Masamitsu Hyodo and Tada‐aki Hori},
  journal={Somatic cell and molecular genetics},
  year={1990},
  volume={16 5},
  pages={461-76}
}
Twenty-five temperature-sensitive (ts) mutants were isolated from Chinese hamster CHO-K1 cells after mutagenization with N-methyl-N'-nitro-N-nitrosoguanidine. Of 13 complementation groups identified, nine exhibited chromosomal instability at a nonpermissive temperature. They were classified into three major classes according to inducibility of sister chromatid exchange (SCE) and/or chromosomal aberration (CA): class 1 resulted in predominant SCEs, class 2 manifested both SCEs and CAs, and class… CONTINUE READING
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