Corpus ID: 43620569

Isolation of steroidal sapogenins implicated in experimentally induced cholangiopathy of sheep grazing Brachiaria decumbens in Brazil.

  title={Isolation of steroidal sapogenins implicated in experimentally induced cholangiopathy of sheep grazing Brachiaria decumbens in Brazil.},
  author={Cl{\'a}udio E. F. Cruz and David Driemeier and Viviane Silva Pires and Edson Moleta Colodel and Alexandre Toshirrico Cardoso Taketa and Eloir Paulo Schenkel},
  journal={Veterinary and human toxicology},
  volume={42 3},
As part of an experimental study, crystal-associated cholangiopathy was induced in 9 sheep by grazing pure pastures of Brachiaria decumbens in Brazil. One of these sheep showed characteristic lesions of photosensitization. The analysis of the B decumbens samples by acidic hydrolysis followed by TLC and infrared spectrum revealed diosgenin as the principal sapogenin present in the plant. In the rumen contents samples from the B decumbens-grazing group were identified by TLC, 1H and 13C NMR and… Expand
Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin 1
Brum K.B., Haraguchi M., Lemos R.A.A, Riet-Correa F. & Fioravanti M.C.S. 2007. Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin. PesquisaExpand
Study of experimentally induced lesions in sheep by grazing Brachiaria decumbens.
Findings suggest that hepatocytes were the initial target of the toxic effects, which depending on the degree of severity developed would cause both, subsequent cholangiopathy or occasional photosensitization. Expand
Intoxicação experimental por Brachiaria decumbens em ovinos confinados
Serum biochemistry results of GGT suggest that they are useful for a precocious diagnosis preventing deaths caused by ingestion of B. decumbens toxicosis in sheep. Expand
Hepatic photosensitization in buffaloes intoxicated by Brachiaria decumbens in Minas Gerais state, Brazil.
Findings indicate that the grass was more toxic in this period of outbreaks provoked by ingestion of Brachiaria decumbens in Minas Gerais state, Brazil, and there was a positive correlation between saponin and the amount of rainfall, as well as between sapons and green leaves in the pasture. Expand
Experimentally Induced Cholangiohepatopathy by Dosing Sheep with Fractionated Extracts from Brachiaria Decumbens
  • C. Cruz, D. Driemeier, V. Pires, E. Schenkel
  • Biology, Medicine
  • Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2001
Cholangiohepatopathy was induced in 5 lambs by oral administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout theExpand
Lectin histochemistry of foam cells in tissues of cattle grazing Brachiaria spp.
The lectin peanut agglutinin was found to be an excellent marker to differentiate and quantify the foam cells, and could be used as a specific marker. Expand
Colangiopatia associada a cristais em ovinos alimentados com Brachiaria decumbens que contém a saponina protodioscina
An outbreak of hepatogenous photosensitization in a flock of 28 sheep grazing Brachiaria decumbens in Mato Grosso do Sul State, Central-Western Brazil, and 6 of them died should be an important limiting factor for the sheep industry. Expand
Steroidal saponin concentrations in Brachiaria decumbens and B. brizantha at different developmental stages
The levels of a steroidal saponin, protodioscin, in the seeds and aerial parts of B. brizantha and B. decumbens during different developmental stages (growth, bloom, fructification and seed fall) were presented. Expand
Intoxicação por Brachiaria spp. em ruminantes no Brasil
Main preventive measures are based on the selection of resistant or resilient animals and on the development of Brachiaria species or varieties with low saponin concentration. Expand
Can treatment of Brachiaria decumbens (signal grass) improve its utilisation in the diet in small ruminants?—a review
Biological treatments using urea, activated charcoal, polyethylene glycol, and effective microorganisms were found to be useful in anti-nutritional factor deactivation and improving the nutritive values of feedstuffs and oral administration of phenobarbitone showed some degree of protection in sheep that fed on B. decumbens pasture. Expand