Isolation of pleuturegin, a novel ribosome-inactivating protein from fresh sclerotia of the edible mushroom Pleurotus tuber-regium.

@article{Wang2001IsolationOP,
  title={Isolation of pleuturegin, a novel ribosome-inactivating protein from fresh sclerotia of the edible mushroom Pleurotus tuber-regium.},
  author={Hexiang Wang and Tzi Bun Ng},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={288 3},
  pages={
          718-21
        }
}
A ribosome-inactivating protein (RIP) designated pleuturegin, which inhibited translation in a cell-free rabbit reticulocyte lysate system with an IC50 of 0.5 nM, was purified from fresh sclerotia of the edible mushroom Pleurotus tuber-regium. Pleuturegin was distinguished from most plant and previously reported mushroom RIPs in that it was adsorbed on DEAE-cellulose and unadsorbed on SP-Sepharose, although all of them were adsorbed on Affi-gel blue gel. Pleuturegin demonstrated an N-terminal… CONTINUE READING
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