Isolation of opiate receptor ligands in coffee.

  title={Isolation of opiate receptor ligands in coffee.},
  author={Kamil Wynne and Mary Familari and Jaroslav H. Boublik and OlafH. Drummer and Ian D. Rae and John W. Funder},
  journal={Clinical and experimental pharmacology & physiology},
  volume={14 10},
1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chromatography. 3. Examination of the final concentrate by GC-MS showed the presence of a number of isomeric (iso)feruloylquinic acid lactones. 4. It is suggested that the synthesis… CONTINUE READING