Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.

@article{Mori2003IsolationON,
  title={Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.},
  author={Y. Mori and K. Kamata and N. Toda and H. Hayashi and K. Seki and S. Taneda and S. Yoshino and A. Sakushima and M. Sakata and A. Suzuki},
  journal={Biological \& pharmaceutical bulletin},
  year={2003},
  volume={26 3},
  pages={
          394-5
        }
}
The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities. 
Investigation of Vasodilatory Substances in Diesel Exhaust Particles (DEP): Isolation and Identification of Nitrophenol Derivatives
Vasodilatory compounds in the weak acidic fraction of a benzene extract of diesel exhaust particles (DEP) were fractionated by column chromatography through silica gel, and the chemical structures ofExpand
Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP).
TLDR
Anti-androgenicity is found in all four nitrophenols isolated from diesel exhaust particles (DEP) because these compounds are alkylphenolic derivatives that might mimic hormones. Expand
Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles
TLDR
Results clearly show the estrogenic activity of PNMC and PNMPP by cell proliferation on the uterine luminal epithelium as well as vasodilators and xenoestrogens. Expand
Estrogenic Activities of Nitrophenols in Diesel Exhaust Particles1
TLDR
It is demonstrated that PNMC and PNMPP in DEP have estrogenic activity both in vitro and in vivo and might therefore be considered as endocrine-disrupting chemicals. Expand
Isolation and identification of new vasodilative substances in diesel exhaust particles
  • K. Seki, Y. Noya, +4 authors K. Ohkura
  • Chemistry, Medicine
  • Environmental science and pollution research international
  • 2010
TLDR
A new fractionation method for DEP has made possible the isolation of new vasodilative compounds from the sodium bicarbonate extract, including 4-Hydroxy-3-nitrobenzoic acid, and 3-hydroxy-4-nitrogenic acid. Expand
Nitrophenols isolated from diesel exhaust particles promote the growth of MCF-7 breast adenocarcinoma cells.
TLDR
Results clearly indicate that PNMC and PNMPP do not show genotoxicity but act as tumor promoters in an estrogen receptor alpha-predominant breast cancer cell line. Expand
Effects of 3-methyl-4-nitrophenol in diesel exhaust particles on the regulation of testicular function in immature male rats.
TLDR
It is suggested that PNMC has a direct effect on the testes of immature male rats, causing a reduction in testosterone secretion. Expand
4-Nitrophenol isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats
TLDR
Findings clearly show that PNP influences the hypothalamic–pituitary–gonadal axis in immature male rats, with decreased secretion of LH and FSH and increased secretion of testosterone and inhibin. Expand
Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line.
TLDR
S steroidogenic enzymes are clarified as candidates responsible for the inhibition or stimulation for the production of steroid hormones in the steroidogenic pathway, thus providing the first experimental evidence for multiple mechanisms of disruption of endocrine pathways by these nitrophenols. Expand
Anti-androgenic activity of 3-methyl-4-nitrophenol in diesel exhaust particles.
TLDR
The results demonstrate that PNMC in diesel exhaust particles clearly has anti-androgenic activity both in vitro and in vivo and can therefore be considered as an endocrine-disrupting chemical. Expand
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