Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.

@article{Fehon1997IsolationOM,
  title={Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.},
  author={Richard G Fehon and Tal Oren and Dennis R LaJeunesse and Thomas E. Melby and Brooke M. McCartney},
  journal={Genetics},
  year={1997},
  volume={146 1},
  pages={245-52}
}
Reverse genetic analysis in Drosophila has been greatly aided by a growing collection of lethal P transposable element insertions that provide molecular tags for the identification of essential genetic loci. However, because the screens performed to date primarily have generated autosomal P-element insertions, this collection has not been as useful for performing reverse genetic analysis of X-linked genes. We have designed a reverse genetic screen that takes advantage of the hemizygosity of the… CONTINUE READING
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