Isolation of mutant Saccharomyces cerevisiae strains that survive without sphingolipids.

@article{Dickson1990IsolationOM,
  title={Isolation of mutant Saccharomyces cerevisiae strains that survive without sphingolipids.},
  author={Robert C. Dickson and Gregg B. Wells and Ansgar Schmidt and Robert L. Lester},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 5},
  pages={2176-81}
}
Sphingolipids comprise a large, widespread family of complex eucaryotic-membrane constituents of poorly defined function. The yeast Saccharomyces cerevisiae is particularly suited for studies of sphingolipid function because it contains a small number of sphingolipids and is amenable to molecular genetic analysis. Moreover, it is the only eucaryote in which mutants blocked in sphingolipid biosynthesis have been isolated. Beginning with a nonreverting sphingolipid-defective strain that requires… CONTINUE READING

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