Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription.

@article{Wu1999IsolationOM,
  title={Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription.},
  author={Si Ying Wu and Mary C. Thomas and Samuel Y Hou and Vilas V. Likhite and C M Chiang},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 33},
  pages={23480-90}
}
TFIID is a general transcription factor required for the assembly of the transcription machinery on most eukaryotic promoters transcribed by RNA polymerase II. Although the TATA-binding subunit (TBP) of TFIID is able to support core promoter and activator-dependent transcription under some circumstances, the roles of TBP-associated factors (TAF(II)s) in TFIID-mediated activation remain unclear. To define the evolutionarily conserved function of TFIID and to elucidate the roles of TAF(II)s in… CONTINUE READING

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