Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.

@article{Lerner1991IsolationOM,
  title={Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.},
  author={Ethan A Lerner and J M C Ramalho Ribeiro and Randy J Nelson and Megan Lerner},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 17},
  pages={11234-6}
}
Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan. 

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