Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.

@article{Selkoe1986IsolationOL,
  title={Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.},
  author={Dennis J Selkoe and Carmela R. Abraham and Marcia B Podlisny and Lawrence K. Duffy},
  journal={Journal of neurochemistry},
  year={1986},
  volume={46 6},
  pages={1820-34}
}
During aging of the human brain, and particularly in Alzheimer's disease, progressive neuronal loss is accompanied by the formation of highly stable intra- and extraneuronal protein fibers. Using fluorescence-activated particle sorting, a method has been developed for purifying essentially to homogeneity the extracellular amyloid fibers that form the cores of senile plaques. The purified plaque cores each contain 60-130 pg of protein. Their amino acid composition shows abundant glycine, trace… CONTINUE READING

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