Isolation of hsp70-binding proteins from bovine muscle.

  title={Isolation of hsp70-binding proteins from bovine muscle.},
  author={Boris A Margulis and Michael Welsh},
  journal={Biochemical and biophysical research communications},
  volume={178 1},
It has been proposed that the members of the hsp70 major heat shock protein family in non-stressed cells participate in the intracellular transport of newly synthesized proteins and in maintaining such proteins in an unfolded state. Specific binding of other cellular proteins to hsp70 may play a role in hsp70 function. A simple method for isolation of hsp70 binding proteins using hsp70-sepharose column chromatography is described. The column binds hsp70 antibodies and thermodenatured a2… CONTINUE READING


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