Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.

  title={Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.},
  author={Bingcheng Wang and Hongying Yang and Ying Chun Liu and Tom{\'a}s Jel{\'i}nek and Li Zhang and Erkki Ruoslahti and Hua Fu},
  volume={38 38},
The 14-3-3 proteins interact with diverse cellular molecules involved in various signal transduction pathways controlling cell proliferation, transformation, and apoptosis. To aid our investigation of the biological function of 14-3-3 proteins, we have set out to identify high-affinity antagonists. By screening phage display libraries, we have identified a set of peptides which bind 14-3-3 proteins. One of these peptides, termed R18, exhibited a high affinity for different isoforms of 14-3-3… CONTINUE READING
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SWTY--a general peptide probe for homogeneous solution binding assay of 14-3-3 proteins.

Analytical biochemistry • 2006
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