Isolation of heparin-insensitive aortic smooth muscle cells. Growth and differentiation.

@article{Antonio1993IsolationOH,
  title={Isolation of heparin-insensitive aortic smooth muscle cells. Growth and differentiation.},
  author={James D. San Antonio and Morris J. Karnovsky and M E Ottlinger and R Schillig and Laurel Pukac},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1993},
  volume={13 5},
  pages={748-57}
}
Previous work has shown heparin and heparan sulfates to be potent inhibitors of vascular smooth muscle cell (VSMC) growth. This laboratory has previously isolated a VSMC line insensitive to the antiproliferative action of heparin by subjecting VSMCs that grew out from rat aortic medial explants to continuous passage in media containing heparin at 200 micrograms/mL. In the present study, we have isolated two additional heparin-resistant (HR) cell lines and have used the HR cells to investigate… CONTINUE READING

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