Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28.

@article{Jin1999IsolationOF,
  title={Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28.},
  author={Dong-Yan Jin and K T Jeang},
  journal={Journal of biomedical science},
  year={1999},
  volume={6 2},
  pages={115-20}
}
NEMO is an essential component of the IkappaB kinase complex. Others have shown that expression of mouse NEMO can complement the lack of responsiveness to NF-kappaB stimuli in two NEMO-deficient cell lines. Here we report the isolation of a full-length human NEMO cDNA. Virtual translation of human NEMO cDNA predicts a 48-kD coiled-coil protein which shares 87.9% identity and 90.5% similarity with the mouse homolog. By sequence alignment, we mapped the human NEMO gene to chromosome Xq28. We note… CONTINUE READING

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