Isolation of factor Xa from chick embryo as the amniotic endoprotease responsible for paramyxovirus activation

@article{Gotoh1992IsolationOF,
  title={Isolation of factor Xa from chick embryo as the amniotic endoprotease responsible for paramyxovirus activation},
  author={Bin Gotoh and Fumi Yamauchi and T. Ogasawara and Yoshiyuki Nagai},
  journal={FEBS Letters},
  year={1992},
  volume={296}
}
In chick embryo, certain paramyxoviruses mainly target the chorioallantois and the allantoamnion and show no extensive further spreading in the other organs. This has been explained by the possible presence of an endoprotease activating the viral fusion glycoprotein precursor in the allantoic and the amniotic fluid, and its absence in other places or organs, We previously isolated such an endoprotease from the allantoic fluid and demonstrated its identity with the clotting factor Xa. Exactly… 
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An endoprotease from chick embryo is isolated, that activates para‐ and orthomyxovirus fusion glycoproteins by cleaving their precursor proteins at a specific, single arginine site and was found to be highly homologous, if not identical, to the blood clotting factor X(FX), a member of the prothrombin family.
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