Isolation of factor Xa from chick embryo as the amniotic endoprotease responsible for paramyxovirus activation

@article{Gotoh1992IsolationOF,
  title={Isolation of factor Xa from chick embryo as the amniotic endoprotease responsible for paramyxovirus activation},
  author={Bin Gotoh and Fumi Yamauchi and T. Ogasawara and Yoshiyuki Nagai},
  journal={FEBS Letters},
  year={1992},
  volume={296}
}
Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa.
TLDR
Among snake venom procoagulant proteins, group II prothrombin activators are functionally similar to blood coagulation factor Xa, and trocarin is the first true structural homologue of a coagulations factor.
Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation
TLDR
The results show that cleavage efficiency can vary significantly for individual HAs, depending on the protease, and that some HA subtypes display stringent selectivity for specific proteases as activators of fusion function, and also show that there are substantial differences between the subtypes that may influence transmission among hosts and establishment in new species.
Sequence and structure of influenza Hemagglutinin cleavage site modulate viral pathogenesis
TLDR
Insight is provided into the bacterial mediated enhancement of influenza virus infection and pathogenesis by identifying that an amino acid substitution, Ser to Tyr at the P2 position of the HA cleavage site optimizes cleavage by the protease plasmin (Pm).
Paramyxovirus entry.
TLDR
Important functional, biochemical and structural features of the attachment and fusion glycoproteins from a variety of family members are detailed, highlighting the important features of protease cleavage and associated tropism and virulence.
Virus Activation by Host Proteinases. A Pivotal Role in the Spread of Infection, Tissue Tropism and Pathogenicity
  • Y. Nagai
  • Biology
    Microbiology and immunology
  • 1995
TLDR
This work has shown that the fusion (F) glycoprotein of NDV and other paramyxoviruses induces fusion between the viral envelope and host cell membrane, and hence enables the viral genome to enter the target cells.
Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection
TLDR
Pretreatment of mouse and human lung cell lines with the serine protease inhibitors AEBSF or p AB or a cocktail of both prior to infection with the H1N1 or the A/Seal/Massachusetts/1/80 virus resulted in a decrease in virus replication.
Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3
TLDR
The cleavage activity of the mammalian subtilisin-related proteinases furin/PACE, PC2, and PC1/PC3, which are thought to be responsible for proprotein processing in either the constitutivesecretory pathway or the regulated secretory pathway, are examined.
The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication
TLDR
At high concentrations of TW80, hemorrhage-induced mortality was observed in embryos at the early stages of incubation, indicating that its toxicity to the chicken embryos was dose-dependent.
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An endoprotease homologous to the blood clotting factor X as a determinant of viral tropism in chick embryo.
TLDR
An endoprotease from chick embryo is isolated, that activates para‐ and orthomyxovirus fusion glycoproteins by cleaving their precursor proteins at a specific, single arginine site and was found to be highly homologous, if not identical, to the blood clotting factor X(FX), a member of the prothrombin family.
Activation of Sendai virus infectivity by an enzyme in chicken amniotic fluid.
TLDR
Treatment of Sendai virus with chicken amniotic fluid resulted in a 10(3)- to 10(4)-fold increase in infectivity, the development of haemolysing ability, and cleavage of the F glycoprotein, suggesting that SAE may be the natural proteolytic activator of Sendae virus in a soluble form.
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The pathogenic strain Italien and the apathogenic strain Ulster of Newcastle disease virus have been compared with respect to organ tropism and spread of infection in 11-day-old chick embryos. After
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TLDR
Using the inhibitor di‐isopropylfluorophosphate (DIP), it is shown that abrogation of the proteolytic activity of thrombin also results in a loss (greater than 2000 fold) of differentiation reversal activity.
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TLDR
Since these cleavages confer infectivity upon both Sendai and influenza viruses and the ability to induce cell-to-cell fusion upon Sendai virus, the hydrophobic NH2-terminal sequences on F1 and HA2 may play a role in fusion of viral and host-cell membranes.
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