Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol

@inproceedings{Livshts2015IsolationOE,
  title={Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol},
  author={Mikhail A. Livshts and Elena B Khomyakova and Evgeniy G Evtushenko and Vassili N. Lazarev and Nikolay A. Kulemin and Svetlana E. Semina and Edward V. Generozov and Vadim M. Govorun},
  booktitle={Scientific reports},
  year={2015}
}
Exosomes, small (40-100 nm) extracellular membranous vesicles, attract enormous research interest because they are carriers of disease markers and a prospective delivery system for therapeutic agents. Differential centrifugation, the prevalent method of exosome isolation, frequently produces dissimilar and improper results because of the faulty practice of using a common centrifugation protocol with different rotors. Moreover, as recommended by suppliers, adjusting the centrifugation duration… CONTINUE READING
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