Isolation of cytotoxic substance, kalafungin from an alkalophilic actinomycete, Nocardiopsis dassonvillei subsp. prasina.

@article{Tsujibo1990IsolationOC,
  title={Isolation of cytotoxic substance, kalafungin from an alkalophilic actinomycete, Nocardiopsis dassonvillei subsp. prasina.},
  author={Hiroshi Tsujibo and T Sakamoto and Katsushiro Miyamoto and Genjiro Kusano and Masao Ogura and Tōru Hasegawa and Yoshihiko Inamori},
  journal={Chemical \& pharmaceutical bulletin},
  year={1990},
  volume={38 8},
  pages={
          2299-300
        }
}
An alkalophilic actinomycete, strain OPC-553 regarded as Nocardiopsis dassonvillei subsp. prasina, produced the cytotoxic substance, TS-1, which showed a marked inhibitory activity against L5178Y mouse leukemic cell in vitro. The cytotoxicity of TS-1 on this cell was very strong and its ID50 was 0.018 micrograms/ml. Through direct comparison of its spectral data with those of an authentic sample, TS-1 was identified as the antifungal antibiotic, kalafungin, already isolated from the culture… 
Accumulation of a Bioactive Benzoisochromanequinone Compound Kalafungin by a Wild Type Antitumor-Medermycin-Producing Streptomycete Strain
TLDR
Findings suggested that kalafungin and medermycin could be accumulated by the same streptomycete and share their biosynthetic pathway to some extent in this strain.
Antibacterial angucyclinone and α-pyrone derivatives from desert-derived Nocardiopsis dassonvillei HDN 154151.
One new angucyclinone derivative, Kanglemycin N (1), and two new biogenetically related α-Pyrones, nocapyrones U-V (2-3), were isolated from a desert-derived Actinomycete Nocardiopsis dassonvillei
Isolation, structure elucidation and biological activity of angucycline antibiotics from an epiphytic yew streptomycete
In the course of study of epiphytic microorganisms occurring on the surface of roots of Taxus baccata L. a new strain Streptomyces sp. AC113 was isolated. According to 16S ribosomal DNA‐based
Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
TLDR
A new p-terphenyl 1 and a novel p- terphenyl derivative 3 bearing a benzothiazole moiety were isolated from halophilic actinomycete Nocardiopsis gilva YIM 90087 and their structures were elucidated on the basis of the interpretation of spectral data and by comparison of the corresponding data with those reported previously.
Nocardiopsis species: a potential source of bioactive compounds
TLDR
Members of the genus Nocardiopsis have established a place for themselves and are of considerable value in producing compounds with profound bio‐medical applications, and the gene clusters mediating the synthesis of bioactive compounds have been described.
Isolation of Toxigenic NocardiopsisStrains from Indoor Environments and Description of Two NewNocardiopsis Species, N. exhalans sp. nov. andN. umidischolae sp. nov
TLDR
Five indoor Nocardiopsisstrains were xerotolerant, and all five utilized a wide range of substrates, which combined with the production of toxic substances suggests good survival and potential hazard to human health in water-damaged indoor environments.
Streptomyces sodiiphilus sp. nov., a novel alkaliphilic actinomycete.
TLDR
An alkaliphilic actinomycete, strain YIM 80305(T), which was isolated from a muddy sample in Chaka salt lake, Qinghai Province of China, was characterized using a polyphasic approach and formed a distinct clade based on analyses of the almost-complete and 120-nucleotide variable gamma region of the 16S rRNA gene.
Several physiological features of Streptomyces sp. isolate C-1 showing bioactivity against Fusarium sambucinum and Verticillium dahliae
TLDR
Evaluation of relative polarity of the active and pH effects on principle present in the crude showed that this Streptomyces isolate C-1 has polar nature and was rather alkaliphilic.
Isolation, Classification and Antagonistic Properties of Alkalitolerant Actinobacteria from Algerian Saharan Soils
TLDR
The study supports the view that extreme environments contain many novel actinobacteria, which represent an unexplored source for the discovery of biologically active compounds.
Streptomyces lonarensis sp. nov., isolated from Lonar Lake, a meteorite salt water lake in India
TLDR
It is proposed that strain NCL716T represents a novel species of the genus StrePTomyces, for which the name Streptomyces lonarensis sp.
...
1
2
3
...