Isolation of calcium-dependent platelet proteins that interact with actin.

  title={Isolation of calcium-dependent platelet proteins that interact with actin.},
  author={L. Ling-chi Wang and Joseph J. Bryan},
  volume={25 3},
Low Ca2+ extracts of platelets rapidly form an actin gel when warmed to 25 degrees C. The addition of Ca2+ has three effects. At Ca/EGTA = 0.4, the gel begins to contract. Increasing the Ca2+ concentration increases the rate of contraction and reduces the amount of actomyosin gel. Between Ca/EGTA = 0.4 and 0.5, a protease is activated that selectively degrades polypeptides with molecular weight greater than the myosin heavy chain. At Ca/EGTA = 1, about 70% of the total actin is nonsedimentable… CONTINUE READING
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