Isolation of cDNA and genomic clones encoding human pro-alpha 1 (III) collagen. Partial characterization of the 3' end region of the gene.

@article{Chu1985IsolationOC,
  title={Isolation of cDNA and genomic clones encoding human pro-alpha 1 (III) collagen. Partial characterization of the 3' end region of the gene.},
  author={Mon Li Chu and D. Weil and W J de Wet and Michael Bernard and M Sippola and Francesco Ramirez},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 7},
  pages={4357-63}
}
A cDNA library constructed from human fibroblast poly(A+) RNA was screened for the identification of chimeric molecules bearing collagen-specific sequences. Analysis of three of the resulting positive clones showed that they encoded for the COOH-terminal propeptide region of the human Type III collagen. In addition, three overlapping clones covering more than 21 kilobases of the Type III gene were isolated from Charon 4A libraries of human genomic fragments. Identity between these and the cDNA… CONTINUE READING

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