Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.

@article{Ueoka2009IsolationOA,
  title={Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.},
  author={Reiko Ueoka and Akihiro Ito and Miho Izumikawa and Satoko Maeda and Motoki Takagi and Kazuo Shin-Ya and Minoru Yoshida and Rob W. M. van Soest and Shigeki Matsunaga},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2009},
  volume={53 6},
  pages={680-4}
}
Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase. Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle. 

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