Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

@article{Thumm1994IsolationOA,
  title={Isolation of autophagocytosis mutants of Saccharomyces cerevisiae},
  author={Michael Thumm and Ralf Egner and Bruce D. Koch and Martin Schlumpberger and Michael Straub and Marten Veenhuis and Dieter Heinrich Wolf},
  journal={FEBS Letters},
  year={1994},
  volume={349}
}
Autophagosome formation in mammalian cells.
TLDR
Identification and characterization of the mammalian counterparts of the yeast autophagy proteins has facilitated understanding of mammalian autophapy, particularly of autophagosome formation, and these findings are now being applied to studies on the physiological roles of Autophagy in mammals.
Saccharomyces cerevisiae--a model organism for the studies on vacuolar transport.
TLDR
An overview of the current knowledge of vesicle mediated vacuolar transport in the yeast Saccharomyces cerevisiae cells is provided.
From lysosome to proteasome: the power of yeast in the dissection of proteinase function in cellular regulation and waste disposal.
  • D. Wolf
  • Biology, Chemistry
    Cellular and molecular life sciences : CMLS
  • 2004
TLDR
The function of vacuolar (lysosomal) proteolysis was elucidated and the in vivo role of ubiquitin and its relation to the proteasome was uncovered, providing surprising new insights in cellular control in health and disease.
Structure and function of the yeast vacuole and its role in autophagy
  • M. Thumm
  • Biology
    Microscopy research and technique
  • 2000
TLDR
In this review, starvation‐induced autophagy and its relationship to the specific cytoplasm to vacuole targeting (cvt‐) pathway of proaminopeptidase I is discussed and the specific vacuolar uptake and degradation of peroxisomes in Pichia pastoris cells via micro‐ and macroautophagy is discussed.
AUT 1 , a Gene Essential for Autophagocytosis in the Yeast Saccharomyces cerevisiae
TLDR
Deletion of the AUT1 gene had no obvious influence on secretion, fluid phase endocytosis, or vacuolar protein sorting, which supports the idea of autophagocytotic as being a novel route transporting proteins from the cytoplasm to the vacuole.
The Core Molecular Machinery of Autophagosome Formation
TLDR
This chapter summarizes knowledge about the roles and regulation of these core machinery components in autophagosome formation, in both yeast and mammalian systems.
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