Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library

@article{Liu2007IsolationOA,
  title={Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library},
  author={Jinny L. Liu and George P. Anderson and E. R. Goldman},
  journal={BMC Biotechnology},
  year={2007},
  volume={7},
  pages={78 - 78}
}
BACKGROUND Shark heavy chain antibody, also called new antigen receptor (NAR), consists of one single Variable domain (VH), containing only two complementarity-determining regions (CDRs). The antigen binding affinity and specificity are mainly determined by these two CDRs. The good solubility, excellent thermal stability and complex sequence variation of small single domain antibodies (sdAbs) make them attractive alternatives to conventional antibodies. In this report, we construct and… CONTINUE READING
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