Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning

@article{Yuan2007IsolationOA,
  title={Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning},
  author={Qing-an Yuan and Matthew K. Robinson and Heidi H. Simmons and Maria G Russeva and Gregory P. Adams},
  journal={Cancer Immunology, Immunotherapy},
  year={2007},
  volume={57},
  pages={367-378}
}
While cell surface antigens represent the most common targets for antibody-based cancer therapy, isolation of new antibodies specific for these targets from single-chain Fv phage display libraries has been hindered by limitations associated with traditional selection techniques. Solid phase panning is often associated with conformational changes to the target protein due to its immobilization on plastic tubes that can limit the ability of the isolated scFv to bind to conformational epitopes and… CONTINUE READING
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