Isolation of an antiidiotypic antibody with acetylcholine-receptor-like binding properties from myasthenia gravis patients.

Abstract

The network theory predicts that a subpopulation within the antiidiotypic (anti-Id) antibody response will be the internal image of the priming stimulus. In myasthenia gravis, a portion of the anti-acetylcholine-receptor (anti-AChR) antibody repertoire is directed against the ligand-binding site. These antibodies would be expected to elicit an "anti… (More)

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