Isolation of an IL-13-dependent subclone of the B9 cell line useful for the estimation of human IL-13 bioactivity.

@article{Bouteiller1995IsolationOA,
  title={Isolation of an IL-13-dependent subclone of the B9 cell line useful for the estimation of human IL-13 bioactivity.},
  author={C L Bouteiller and R Astruc and Adrian Minty and Pascual Ferrara and Jan Lupker},
  journal={Journal of immunological methods},
  year={1995},
  volume={181 1},
  pages={29-36}
}
A novel sub-clone of the B9 hybridoma cell line (B9-1-3) has been selected by cloning following continuous culture in rhIL-13. This cell line shows an increased sensitivity to both hIL-13 and mIL-4 compared to the parental B9 cell line. The proliferative response to IL-13 can be blocked with an anti-IL-4 receptor monoclonal antibody but not with the soluble IL-4 receptor, suggesting that IL-13- and IL-4-binding receptor subunits are distinct but form part of a common receptor complex. Although… CONTINUE READING

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