Isolation of amniotic stem cell lines with potential for therapy

@article{Coppi2007IsolationOA,
  title={Isolation of amniotic stem cell lines with potential for therapy},
  author={Paolo De Coppi and Georg Bartsch and Minhaj M. Siddiqui and Tao Xu and Cesar Santos and Laura Perin and Gustavo Mostoslavsky and Ang line C. Serre and Evan Y. Snyder and James J. Yoo and Mark E. Furth and Shay Soker and Anthony Atala},
  journal={Nature Biotechnology},
  year={2007},
  volume={25},
  pages={100-106}
}
Stem cells capable of differentiating to multiple lineages may be valuable for therapy. We report the isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers. Undifferentiated AFS cells expand extensively without feeders, double in 36 h and are not tumorigenic. Lines maintained for over 250 population doublings retained long telomeres and a normal karyotype. AFS cells are broadly multipotent. Clonal human lines verified by… 
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The possible application of human genetically unmodified pluripotent stem cells as well as induced pluripoline stem cells for regenerative medicine is discussed.
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References

SHOWING 1-10 OF 59 REFERENCES
Derivation of pluripotent stem cells from cultured human primordial germ cells.
TLDR
Based on their origin and demonstrated properties, these human PGC-derived cultures meet the criteria for pluripotent stem cells and most closely resemble EG cells.
Adult rat and human bone marrow stromal cells differentiate into neurons
TLDR
Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
Characterization and differentiation of human embryonic stem cells.
TLDR
Qualitative analyses demonstrate that all of the cell lines examined show consistent marker expression and retain a normal karyotype after long-term culture, indicating that they may be an appropriate source of cells for multiple regenerative medicine applications.
Embryonic stem cell lines derived from human blastocysts.
Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
  • G. Martin
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1981
TLDR
The establishment directly from normal preimplantation mouse embryos of a cell line that forms teratocarcinomas when injected into mice makes feasible the isolation of pluripotent cells lines from various types of noninbred embryo, including those carrying mutant genes.
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.
TLDR
MAPCs, derived from normal human, mouse, and rat postnatal bone marrow primitive, multipotent adult progenitor cells, can differentiate into cells with morphological, phenotypic, and functional characteristics of hepatocytes, and may be an ideal cell for in vivo therapies for liver disorders or for use in bioartificial liver devices.
Hepatic maturation in differentiating embryonic stem cells in vitro
Derivation of midbrain dopamine neurons from human embryonic stem cells.
  • A. Perrier, V. Tabar, L. Studer
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Conditions to direct hES cells into neurons of midbrain dopaminergic identity are described and high-yield DA neuron derivation was confirmed from three independent hES and two monkey embryonic stem cell lines.
Neurogenic cells in human amniotic fluid.
...
1
2
3
4
5
...