Isolation of amniotic stem cell lines with potential for therapy

@article{Coppi2007IsolationOA,
  title={Isolation of amniotic stem cell lines with potential for therapy},
  author={P. Coppi and G. Bartsch and M. M. Siddiqui and T. Xu and C. Santos and L. Perin and G. Mostoslavsky and A. Serre and E. Snyder and J. Yoo and M. Furth and S. Soker and A. Atala},
  journal={Nature Biotechnology},
  year={2007},
  volume={25},
  pages={100-106}
}
Stem cells capable of differentiating to multiple lineages may be valuable for therapy. We report the isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers. Undifferentiated AFS cells expand extensively without feeders, double in 36 h and are not tumorigenic. Lines maintained for over 250 population doublings retained long telomeres and a normal karyotype. AFS cells are broadly multipotent. Clonal human lines verified by… Expand
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