Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii

  title={Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii},
  author={R. V. van Rijn and I. K. Rhee and R. Verpoorte},
  journal={Natural Product Research},
  pages={222 - 225}
  • R. V. van Rijn, I. K. Rhee, R. Verpoorte
  • Published 2010
  • Biology, Medicine
  • Natural Product Research
  • Alzheimer's disease (AD) is associated with a steady loss of attention and memory, which has been correlated with the impairment of brain cholinergic neurotransmission, particularly a deficit of cholinergic neurons in the nucleus basalis of Meynert. Therefore, one of the methods that has proven successful in the treatment of AD is the use of inhibitors of acetylcholinesterase (AchE) to supplement the acetylcholine level. Herein we describe the isolation of several AchE-inhibiting alkaloids from… CONTINUE READING
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