Isolation of a transforming sequence from a human bladder carcinoma cell line

@article{Shih1982IsolationOA,
  title={Isolation of a transforming sequence from a human bladder carcinoma cell line},
  author={C. Shih and R. Weinberg},
  journal={Cell},
  year={1982},
  volume={29},
  pages={161-169}
}
We have isolated the component of human bladder carcinoma cell DNA that is able to transform mouse fibroblasts. The oncogenic sequence was isolated initially from a lambda phage genomic library made from DNA of a transfected mouse cell carrying the human oncogene. A subcloned insert of 6.6 kb that carried transforming activity was amplified in the plasmid vector pBR322. The subcloned oncogene has been used as a sequence probe in Southern blot analyses. The oncogene appears to derive from… Expand
655 Citations
Transforming genes in human tumors
  • 58
Alteration of the genomes of tumor cells
  • 19
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.
  • 412
  • PDF
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
  • 197
Activation of related transforming genes in mouse and human mammary carcinomas.
  • M. Lane, A. Sainten, G. Cooper
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1981
  • 116
  • PDF
Isolation and localization of DNA segments from specific human chromosomes.
  • J. Gusella, C. Keys, +4 authors D. Housman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1980
  • 167
  • PDF
Transforming activity of human tumor DNAs.
  • T. G. Krontiris, G. Cooper
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1981
  • 311
  • Highly Influential
  • PDF
...
1
2
3
4
5
...