Isolation of a transforming sequence from a human bladder carcinoma cell line

@article{Shih1982IsolationOA,
  title={Isolation of a transforming sequence from a human bladder carcinoma cell line},
  author={Chiaho Shih and Robert A. Weinberg},
  journal={Cell},
  year={1982},
  volume={29},
  pages={161-169}
}

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DNAs obtained from human, rabbit and mouse bladder carcinomas lines, a lung carcinoma line and rat neuroblastoma and mouse glioma lines, are able to induce transformation of NIH3T3 cells on transfection.
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These experiments prove that in five mouse and rat cell lines the chemically induced phenotype is encoded in DNA, and the sequences specifying the transformed phenotype behave as a dominant allele in the NIH3T3 recipient cells.
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  • T. Krontiris, G. Cooper
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1981
TLDR
It is suggested that dominant mutations or gene rearrangements can result in the activation of cellular transforming genes in some human tumors.
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