Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.

@article{Cabral1981IsolationOA,
  title={Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.},
  author={Fernando A. Cabral and Irene Abraham and Michael M. Gottesman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 7},
  pages={
          4388-91
        }
}
  • Fernando A. Cabral, Irene Abraham, Michael M. Gottesman
  • Published in
    Proceedings of the National…
    1981
  • Biology, Medicine
  • Taxol is a plant alkaloid that has antimitotic activity and appears to stabilize microtubules [Schiff, P. B., Fant, J. & Horwitz, S. B. (1979) Nature (London) 277, 665-667]. Taxol-resistant cells were selected from a population of UV-mutagen-treated Chinese hamster ovary cells by a single-step procedure. These mutants have normal morphologies and growth rates but are 2- to 3-fold more resistant to the toxic effects of the drug than the wild-type parent. One out of 20 mutants screened by two… CONTINUE READING

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