Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant.

@article{Lee2000IsolationOA,
  title={Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant.},
  author={Jongwoo Lee and Joseph R. Prohaska and Susan L. Dagenais and Thomas W. Glover and Dennis J Thiele},
  journal={Gene},
  year={2000},
  volume={254 1-2},
  pages={87-96}
}
A polymerase chain reaction (PCR)-based strategy was used to isolate a mouse cDNA (mCtr1) encoding a Cu transport protein. The deduced mCtr1 protein sequence exhibits 92% identity to human Ctr1, and has structural features in common with known high affinity Cu transporters from yeast. The expression of mouse Ctr1 functionally complements baker's yeast cells defective in high affinity Cu transport. Characterization of the mCtr1 genomic clone showed that the mCtr1 coding sequence is encompassed… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 24 references

Genetic disorders of membrane transport . IV . Wilson ’ s disease and Menkes disease . Am . J . Physiol . 276 , repression of yeast genes encoding critical components in the copper transport pathway

J. D. Gitlin
J . Biol . Chem • 1999
View 1 Excerpt

Pipes and wiring : the regulation of copper mine beta - monooxygenase mRNA and activity

S. Labbé, D. J. Thiele
J . Nutr . Trends Microbiol . • 1999
View 2 Excerpts

Biochim . Biophys . Acta 1360 , trolled expression of heterologous proteins in di ff erent genetic backgrounds

D. J. Eide
1998
View 1 Excerpt

Dynamic regulation ofcals , transition metals and diseases

M. M. Pena, K. A. Koch, D. J. Thiele
Biochem . J . • 1998
View 2 Excerpts

Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces

J. D. Gitlin
1997

Copper biochemistry and molecular biology

C. Vulpe, B. Levinson, +5 authors J. L. O’Claray
Am . J . Clin . Nutr . • 1996

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