Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.

@article{Lecchi2002IsolationOA,
  title={Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.},
  author={Marzia Lecchi and Elisa Redaelli and Barbara Rosati and Georgina B. Gurrola and Tullio Florio and Olivia Crociani and Giulia Curia and Rita Restano Cassulini and Alessio Masi and Annarosa Arcangeli and Massimo Olivotto and Gennaro Schettini and Lourival Domingos Possani and Enzo Wanke},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 9},
  pages={3414-25}
}
Native rat lactotrophs express thyrotrophin-releasing hormone-dependent K+ currents consisting of fast and slow deactivating components that are both sensitive to the class III anti-arrhythmic drugs that block the eag-related gene (ERG) K+ current (I(ERG)). Here we describe in MMQ prolactin-releasing pituitary cells the isolation of the slowly deactivating long-lasting component (I(ERGS)), which, unlike the fast component (I(ERGF)), is insensitive to verapamil 2 microm but sensitive to a novel… CONTINUE READING

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