Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake.

Abstract

A clone has been isolated from a Chinese hamster ovary cell cDNA expression library that complements mutant cells defective in the uptake of the folate analogue methotrexate. When transfected with this clone, the mutant cells regain the ability to bind and transport the drug and, as a consequence, become sensitive to its cytotoxic action. The clone is 2314… (More)

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Cite this paper

@article{Williams1994IsolationOA, title={Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake.}, author={Frederick M R Williams and R. Charles Murray and T. Michael Underhill and Wayne F. Flintoff}, journal={The Journal of biological chemistry}, year={1994}, volume={269 8}, pages={5810-6} }