Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.

@article{Bergelson1997IsolationOA,
  title={Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.},
  author={Jeffrey M. Bergelson and John A Cunningham and Gustavo Droguett and Evelyn A Kurt-Jones and Anita Krithivas and Jason S. Hong and Marshall S Horwitz and Richard L. Crowell and Robert W. Finberg},
  journal={Science},
  year={1997},
  volume={275 5304},
  pages={1320-3}
}
A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in… CONTINUE READING
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