Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation.


HIV-1 latency in resting CD4(+) T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). Eliminating the latent HIV-1 reservoir may require the reactivation of viral gene expression in latently infected cells. Most approaches for reactivating latent HIV-1 require nonspecific T cell activation… (More)
DOI: 10.1073/pnas.0809536106


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