Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3.

@article{Green1987IsolationOA,
  title={Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3.},
  author={Fiona Green and Yvonne H. Edwards and H P Hauri and Sue Povey and Mae Wan Ho and Maximina R Pinto and Dallas Swallow},
  journal={Gene},
  year={1987},
  volume={57 1},
  pages={101-10}
}
We report the nucleotide sequence and derived amino acid sequence of a cDNA clone encoding most of the N-terminal, isomaltase region of human sucrase-isomaltase (SI). A plasmid containing this cDNA, pS12, identifies a 6-kb mRNA found in human jejunum and the human colon carcinoma cell line Caco-2. This human SI cDNA shows extensive overall homology with recently published rabbit SI cDNA. Using pS12 to probe DNA from a panel of somatic cell hybrids, we have assigned the gene encoding human SI to… CONTINUE READING

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