Isolation of a cDNA clone for human antithrombin III.

  title={Isolation of a cDNA clone for human antithrombin III.},
  author={Edward V. Prochownik and Alex F. Markham and Stuart H Orkin},
  journal={The Journal of biological chemistry},
  volume={258 13},
Antithrombin III (ATIII) is an important plasma protease inhibitor with a central role in the coagulation system. On the basis of its protein sequence, ATIII is one member of a "super family" of protease inhibitors that includes alpha 1-antitrypsin and chicken ovalbumin. An increased risk of thromboembolism is associated with inherited ATIII deficiency. To study the structure and expression of the human ATIII gene, we have isolated complementary (cDNA) clones for ATIII from human liver mRNA… CONTINUE READING


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